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Citrus Bergamot 25:1 Extract
Citrus Bergamot 25:1 Extract – Cholesterol & Cardiometabolic Wellness Support
Citrus Bergamot 25:1 Extract is made from Citrus bergamia, a citrus fruit grown mainly in Southern Italy and naturally rich in polyphenols such as neoeriocitrin, naringin, neohesperidin, brutieridin, and melitidin. In wellness supplements, bergamot is best known for its research into cholesterol, triglycerides, and cardiometabolic health markers. Human studies have investigated bergamot extracts in adults with elevated cholesterol, metabolic syndrome, and related cardiometabolic risk factors.
Potential Health Benefits of Citrus Bergamot
Supports healthy cholesterol and lipid metabolism
May assist triglyceride and cardiometabolic marker support
Provides polyphenol-rich antioxidant compounds from Citrus bergamia
Further Information
Traditional & Historical Use
Bergamot fruit has long been associated with Calabria in Southern Italy, where it has been valued for its aromatic peel, essential oil, and citrus-derived compounds. Modern supplement research focuses on bergamot fruit extract and bergamot polyphenolic fraction rather than bergamot essential oil, with human studies investigating its effects on cholesterol, triglycerides, and selected cardiometabolic markers.
Cholesterol & Lipid Metabolism Research
A systematic review evaluating bergamot in humans found that bergamot supplementation was associated with improvements in lipid parameters, particularly total cholesterol, LDL cholesterol, and triglycerides, although the authors noted variation in study design, formulations, and participant groups. Clinical reviews also describe multiple human trials where orally administered bergamot preparations reduced total cholesterol and LDL cholesterol in people with hypercholesterolaemia.
Triglyceride & Cardiometabolic Marker Research
Human studies have investigated bergamot extract in adults with dyslipidaemia, obesity, or cardiometabolic risk factors. A 12-week study of Citrus bergamia extract reported reductions in cholesterol, triglycerides, LDL-C, glucose, and body weight markers in participants with dyslipidaemia and obesity, while newer clinical studies continue to assess standardised bergamot extracts for lipid profile support.
Polyphenol & Antioxidant Research
Bergamot contains polyphenols and flavonoids that have been studied for antioxidant and metabolic activity. Reviews identify compounds such as neoeriocitrin, naringin, neohesperidin, brutieridin, and melitidin as key constituents of bergamot extract, with research exploring their relationship to lipid metabolism and oxidative balance.
Safety & Considerations
Citrus bergamot extract has generally been reported as well tolerated in human studies lasting from 30 days to 12 weeks, although individual suitability may vary. People who are pregnant, breastfeeding, taking prescription medications, using cholesterol-lowering, blood pressure, diabetes, liver, kidney, or cardiovascular medications, or managing any underlying health condition should consult a qualified healthcare professional before use. Bergamot extract supplements are different from bergamot essential oil, which has separate safety considerations and should not be consumed unless specifically formulated and directed for internal use. As with all supplements, use only as directed and seek medical advice before consuming if unsure whether this product is suitable for your individual needs.
References
Effect of bergamot on lipid profile in humans: A systematic review
https://pubmed.ncbi.nlm.nih.gov/31670973/Clinical application of bergamot (Citrus bergamia) for reducing high cholesterol and cardiovascular disease markers
https://pmc.ncbi.nlm.nih.gov/articles/PMC6497409/Effects of 12-week supplementation of Citrus bergamia extracts-based formulation on cardiometabolic risk factors in dyslipidemic overweight/obese subjects
https://pubmed.ncbi.nlm.nih.gov/29273027/Effects of 12-week supplementation of Citrus bergamia extracts-based formulation — PMC full text
https://pmc.ncbi.nlm.nih.gov/articles/PMC5741859/Effect of Citrus bergamia extract on lipid profile: A combined in vitro and human study
https://pubmed.ncbi.nlm.nih.gov/37312672/Citrus bergamia Extract, a Natural Approach for Cholesterol and Lipid Management: A 6-Month Placebo-Controlled Clinical Trial
https://pubmed.ncbi.nlm.nih.gov/39682955/Efficacy of bergamot: From anti-inflammatory and antioxidant mechanisms to clinical applications as preventive agent for cardiovascular morbidity, skin diseases, and mood alterations
https://pmc.ncbi.nlm.nih.gov/articles/PMC6392855/
Citrus Bergamot 25:1 Extract – Cholesterol & Cardiometabolic Wellness Support
Citrus Bergamot 25:1 Extract is made from Citrus bergamia, a citrus fruit grown mainly in Southern Italy and naturally rich in polyphenols such as neoeriocitrin, naringin, neohesperidin, brutieridin, and melitidin. In wellness supplements, bergamot is best known for its research into cholesterol, triglycerides, and cardiometabolic health markers. Human studies have investigated bergamot extracts in adults with elevated cholesterol, metabolic syndrome, and related cardiometabolic risk factors.
Potential Health Benefits of Citrus Bergamot
Supports healthy cholesterol and lipid metabolism
May assist triglyceride and cardiometabolic marker support
Provides polyphenol-rich antioxidant compounds from Citrus bergamia
Further Information
Traditional & Historical Use
Bergamot fruit has long been associated with Calabria in Southern Italy, where it has been valued for its aromatic peel, essential oil, and citrus-derived compounds. Modern supplement research focuses on bergamot fruit extract and bergamot polyphenolic fraction rather than bergamot essential oil, with human studies investigating its effects on cholesterol, triglycerides, and selected cardiometabolic markers.
Cholesterol & Lipid Metabolism Research
A systematic review evaluating bergamot in humans found that bergamot supplementation was associated with improvements in lipid parameters, particularly total cholesterol, LDL cholesterol, and triglycerides, although the authors noted variation in study design, formulations, and participant groups. Clinical reviews also describe multiple human trials where orally administered bergamot preparations reduced total cholesterol and LDL cholesterol in people with hypercholesterolaemia.
Triglyceride & Cardiometabolic Marker Research
Human studies have investigated bergamot extract in adults with dyslipidaemia, obesity, or cardiometabolic risk factors. A 12-week study of Citrus bergamia extract reported reductions in cholesterol, triglycerides, LDL-C, glucose, and body weight markers in participants with dyslipidaemia and obesity, while newer clinical studies continue to assess standardised bergamot extracts for lipid profile support.
Polyphenol & Antioxidant Research
Bergamot contains polyphenols and flavonoids that have been studied for antioxidant and metabolic activity. Reviews identify compounds such as neoeriocitrin, naringin, neohesperidin, brutieridin, and melitidin as key constituents of bergamot extract, with research exploring their relationship to lipid metabolism and oxidative balance.
Safety & Considerations
Citrus bergamot extract has generally been reported as well tolerated in human studies lasting from 30 days to 12 weeks, although individual suitability may vary. People who are pregnant, breastfeeding, taking prescription medications, using cholesterol-lowering, blood pressure, diabetes, liver, kidney, or cardiovascular medications, or managing any underlying health condition should consult a qualified healthcare professional before use. Bergamot extract supplements are different from bergamot essential oil, which has separate safety considerations and should not be consumed unless specifically formulated and directed for internal use. As with all supplements, use only as directed and seek medical advice before consuming if unsure whether this product is suitable for your individual needs.
References
Effect of bergamot on lipid profile in humans: A systematic review
https://pubmed.ncbi.nlm.nih.gov/31670973/Clinical application of bergamot (Citrus bergamia) for reducing high cholesterol and cardiovascular disease markers
https://pmc.ncbi.nlm.nih.gov/articles/PMC6497409/Effects of 12-week supplementation of Citrus bergamia extracts-based formulation on cardiometabolic risk factors in dyslipidemic overweight/obese subjects
https://pubmed.ncbi.nlm.nih.gov/29273027/Effects of 12-week supplementation of Citrus bergamia extracts-based formulation — PMC full text
https://pmc.ncbi.nlm.nih.gov/articles/PMC5741859/Effect of Citrus bergamia extract on lipid profile: A combined in vitro and human study
https://pubmed.ncbi.nlm.nih.gov/37312672/Citrus bergamia Extract, a Natural Approach for Cholesterol and Lipid Management: A 6-Month Placebo-Controlled Clinical Trial
https://pubmed.ncbi.nlm.nih.gov/39682955/Efficacy of bergamot: From anti-inflammatory and antioxidant mechanisms to clinical applications as preventive agent for cardiovascular morbidity, skin diseases, and mood alterations
https://pmc.ncbi.nlm.nih.gov/articles/PMC6392855/