HMB + Vitamin D3

Nutricost HMB + Vitamin D3 – Muscle Strength & Function Support

Nutricost HMB + Vitamin D3 combines HMB, a metabolite of the essential amino acid leucine, with vitamin D3, a nutrient involved in muscle function, bone health, and overall wellbeing. HMB has been studied for its role in muscle protein balance, strength, and physical function, while vitamin D3 is especially relevant to muscle health in people with low vitamin D status. Human research on HMB plus vitamin D3 has focused mainly on middle-aged and older adults, where studies have investigated muscle strength, physical function, lean mass, and functional performance.

Potential Health Benefits of HMB + Vitamin D3

• Supports muscle strength and physical function in studied adult populations

• Assists lean muscle maintenance and muscle protein balance research

• Supports vitamin D status, muscle function, and bone health

Further Information

Traditional & Historical Use

HMB and vitamin D3 are not traditional herbal ingredients. HMB is naturally produced in small amounts when the body metabolises leucine, an amino acid found in protein-rich foods such as meat, fish, eggs, and dairy. Vitamin D3 is produced in the skin through sunlight exposure and is also found in some foods and supplements. Modern research has focused on HMB for muscle protein balance and functional performance, while vitamin D3 has long been studied for bone, muscle, and immune health.

Muscle Strength & Physical Function Research

A 12-month randomised, double-blind, placebo-controlled trial in adults over 60 found that HMB plus vitamin D3 improved muscle strength and physical functionality, even without exercise training. In participants who also exercised, the combination supported additional functional outcomes. This research directly supports HMB plus vitamin D3 as a muscle strength and function support formula in older adult populations.

Muscle Mass & Lean Tissue Support

HMB has been studied for its role in helping preserve muscle mass, particularly in older adults or during periods of reduced activity. A systematic review and meta-analysis found that HMB supplementation contributed to preservation of muscle mass in older adults, while a clinical study in healthy older adults found HMB helped preserve lean body mass during 10 days of bed rest. These findings support HMB’s role in muscle maintenance research, especially when paired with adequate protein intake and healthy movement habits.

Vitamin D3 & Muscle Function

Vitamin D plays an important role in musculoskeletal health, including calcium regulation, bone health, and muscle function. In HMB plus vitamin D3 research, vitamin D status is relevant because insufficient vitamin D may reduce muscle function outcomes, and combined supplementation has been studied in adults where strength and physical performance are key outcomes.

Safety & Considerations

HMB is generally considered well tolerated in studied doses, and vitamin D3 is widely used when taken within recommended intake limits. Vitamin D can accumulate in the body if taken excessively and may contribute to high calcium levels, especially when combined with high-dose vitamin D products or certain medications. Individuals who are pregnant, breastfeeding, taking prescription medications, using calcium or vitamin D supplements, managing kidney disease, high calcium levels, parathyroid conditions, sarcoidosis, cardiovascular disease, or any underlying health condition should consult a qualified healthcare professional before use. As with all supplements, use only as directed and seek medical advice before consuming if unsure whether this product is suitable for your individual needs.

References

1. Long-term Effects of Calcium β-Hydroxy-β-Methylbutyrate and Vitamin D3 Supplementation on Muscular Function in Older Adults With and Without Resistance Training
   https://pmc.ncbi.nlm.nih.gov/articles/PMC7566440/

2. Long-term Effects of Calcium β-Hydroxy-β-Methylbutyrate and Vitamin D3 Supplementation — PubMed Record
   https://pubmed.ncbi.nlm.nih.gov/32857128/

3. Small-Scale Randomized Controlled Trial to Explore the Impact of β-Hydroxy-β-Methylbutyrate Plus Vitamin D3 on Skeletal Muscle in Middle-Aged Women
   https://pmc.ncbi.nlm.nih.gov/articles/PMC9658601/

4. Effect of β-Hydroxy-β-Methylbutyrate Supplementation on Muscle Mass, Strength and Function in Older Adults: A Systematic Review and Meta-Analysis
   https://pubmed.ncbi.nlm.nih.gov/26169182/

5. Effect of β-Hydroxy-β-Methylbutyrate (HMB) on Lean Body Mass During 10 Days of Bed Rest in Older Adults
   https://pubmed.ncbi.nlm.nih.gov/23514626/

6. International Society of Sports Nutrition Position Stand: Beta-Hydroxy-Beta-Methylbutyrate (HMB)
   https://pubmed.ncbi.nlm.nih.gov/23374455/